Amigurumi Double Helix DNA – FREE Crochet Pattern

A plush model of a DNA double helix with colorful ribbed strands standing on a window sill.
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Celebrate science with a twist of yarn using this Amigurumi Double Helix DNA crochet pattern! Inspired by the iconic structure of life itself, this clever design transforms the double helix into a fun and educational piece of fiber art. Whether you’re a biology buff, a teacher looking for a classroom prop, or just love geeky crochet projects, this pattern lets you stitch up a spiraling strand of creativity that’s sure to spark curiosity and conversation. 🧬🧶✨

Designed for playful learning, this pattern invites you to experiment with colorful base pairs, twisty stitches, and clever shaping to bring your DNA strand to life. Add a keychain loop, turn it into a bracelet, or even make a giant version for display—there are so many ways to customize it! Whether you’re crafting for a science fair, a gift for a lab-loving friend, or just for the joy of making something unique, this Amigurumi Double Helix DNA is a fascinating and satisfying project—perfect for bringing a touch of handmade science to every stitch! 💖🔬🌈

A plush model of a DNA double helix with colorful ribbed strands standing on a window sill.

🧬 Amigurumi Double Helix DNA – Free Crochet Pattern

Celebrate science and creativity with this amigurumi DNA sculpture, featuring a beautifully twisted double helix structure with colorful base pairs. This is a stunning piece of décor for a classroom, lab, or science-lover’s shelf – soft, sturdy, and educational!


✨ Skill Level

Intermediate – Involves long tubular shaping, intentional twisting, colorwork, and structural attachment.


📏 Finished Size

Approx. 9–12 inches (23–30 cm) tall when using velvet/bulky yarn and a 4 mm hook.


🧶 Materials

  • Yarn (Bulky chenille or velvet recommended for shape and body)
    • Light blue (backbone strands)
    • Red, orange, yellow, green, purple (base pair rungs)
  • Crochet hook: 4 mm
  • Fiberfill stuffing
  • Pipe cleaners, wire, or floral wire (for structural twist)
  • Stitch markers
  • Yarn needle
  • Optional: weighted base or plastic disc for stability

🧵 Abbreviations (US Terms)

MR – Magic Ring
sc – Single Crochet
inc – Increase
dec – Decrease
ch – Chain
sl st – Slip Stitch
st(s) – Stitch(es)
FO – Fasten Off


🌀 Helix Strands (Make 2)

With light blue yarn:

  1. MR, 6 sc
    2–60. sc around (6)
    Stuff very lightly as you go. Insert wire or pipe cleaner inside as you stuff to help twist and hold shape.

💡 To make it taller, continue to ~80 rows. To shorten, stop at ~50 rows.

FO, leave long tail for shaping.

Repeat for second helix strand.


🧱 Rungs (Base Pairs) – Make 12–15 Pairs

Each rung is crocheted flat in a row and connects the two helix strands.

You can either color-code each base pair with two different yarns (like A–T and C–G) or use a variety of rainbow colors as in the photo.

Basic Rung Pattern:

With any color:

  1. Ch 7
  2. Turn, sc in 2nd ch and across (6)
  3. FO and leave both tails long for sewing.

Make 12–15 total rungs. Each will be spaced evenly along the helix.


🪢 Base Circle Stand (Optional but Recommended)

This round base gives your DNA structure a stable platform.

With light blue yarn:

  1. MR, 6 sc
  2. inc x6 (12)
  3. (1 sc, inc) x6 (18)
  4. (2 sc, inc) x6 (24)
  5. (3 sc, inc) x6 (30)
  6. (4 sc, inc) x6 (36)
  7. (5 sc, inc) x6 (42)
    Continue increasing to desired width (~60–70 sts)
    Work 2 rounds of sc even, FO.

Optional: Insert plastic or cardboard circle inside and whipstitch bottom closed.


🔄 Assembly Instructions

  1. Lay out your two blue helix tubes parallel to each other, spaced 2–3″ apart.
  2. Begin attaching base pair rungs every 5–6 rounds using the yarn tails. Sew both ends of each rung to opposite tubes, pulling slightly to create tension.
  3. As you go, twist the tubes gently around each other. Secure the twist with the wire inside.
  4. Sew the ends of both strands into the center of your round base and secure tightly.
  5. Use invisible stitches to anchor any loose segments and enhance the twist.

🧷 Tips for Structure & Stability

  • Insert floral wire or chenille stems inside both tubes before assembling for better control of the twist.
  • Add a small beanbag or weight pouch into the base circle for extra bottom weight.
  • Use a touch of hot glue inside if you’re using this as a classroom display.

💡 Customization Ideas

  • Label each base pair with felt initials (A–T, C–G)
  • Crochet mini faces or kawaii eyes for a cute plush version
  • Add a hanging loop and use it as science-themed wall art

This crochet DNA helix is a brilliant way to combine STEM and stitches! 🧵🧬


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